C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 167/136,
C12N 15/31 (2006.01) A61K 39/09 (2006.01) C07K 14/315 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2005704
Mutants of pneumolysin that are non-toxic by reason of amino acid substitutions have been constructed. These mutants elicit an immune response in animals that is reactive to wild-type pneumolysin. The invention also encompasses vaccines for humans based on these mutants, including vaccines comprising conjugates with pneumococcal capsular polysaccharides.
Andrew Peter W.
Boulnois Graham J.
Hansman David J.
Mitchell Timothy J.
Paton James C.
Andrew Peter W.
Boulnois Graham J.
de Staat Der Nederlanden Vertegenwoordigd Door de Minister Van W Volksgezondheid En Cultuur
Hansman David J.
Mitchell Timothy J.
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