[1,2,4] triazolo [4,3-b] pyridazines as ligands of the...

Details [1,2,4] triazolo [4,3-b] pyridazines as ligands of the... [1,2,4] triazolo [4,3-b] pyridazines as ligands of the...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2759884

The invention concerns bicyclic compounds of Formula (I): wherein, R1, R2, R3, R4, R5, X1, X2, Y, k, m, n and p are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of androgen- receptor associated conditions, particularly prostate cancer.

La présente invention a pour objet des composés bicycliques de Formule (I), R1, R2, R3, R4, R5, X1, X2, Y, k, m, n et p étant tels que définis dans la description. La présente invention concerne également des procédés pour la préparation de tels composés, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement des états associés au récepteur des androgènes, en particulier du cancer de la prostate.

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