N-(mercaptoacyl)amino acids, methods of their preparation...

Details N-(mercaptoacyl)amino acids, methods of their preparation... N-(mercaptoacyl)amino acids, methods of their preparation...

C - Chemistry, Metallurgy

07

C

C07C 327/34 (2006.01) A61K 31/195 (2006.01) A61K 31/265 (2006.01) A61K 31/33 (2006.01) C07C 323/41 (2006.01) C07C 323/60 (2006.01) C07C 327/32 (2006.01) C07D 207/337 (2006.01) C07D 213/56 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 307/54 (2006.01) C07D 317/60 (2006.01) C07D 333/24 (2006.01)

Patent

CA 2121801

2121801 9308162 PCTABS00021 The present invention is directed to a compound of formula (I), wherein R represents a hydrogen atom or an acyl, aroyl or cycloalkylcarbonyl radical or a residue of formula (Ia); R1 represents an alkyl radical; R2 represents an aryl or heteroaryl radical, or R1 represents an alkylene chain attached to a carbon atom in an ortho position of the R2 aryl or heteroaryl radical relative to a carbon of the R2 aryl or heteroaryl radical linked to the propanoyl moiety; R3 represents a hydrogen atom or an alkyl, aryl, alkoxy or aryloxy radical; and R' represents a hydrogen atom or an alkyl, aralkyl, acyl or aroyl radical; and the pharmaceutically acceptable salts thereof. The invention is also directed to the preparation of these compounds, pharmaceutical compositions comprising the compounds and methods for their pharmaceutical use.

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