1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 249/08 (2006.01)

Patent

CA 2583150

1,2,4 Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4 triazolylaminoaryl(heteroaryl) sulfonamide derivatives and pharmaceutical compositions containing 1,2,4 triazolylaminoaryl (heteroaryl)sulfonamide derivatives are disclosed: Formula (I) The 1,2,4 triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I) possess cell cycle inhibitory activity and are accordingly useful for their anti cell proliferation (such as anti cancer) activity.

La présente invention concerne des dérivés de 1,2,4 triazolylaminoaryl(hétéroaryl)sulfonamide de formule (I), des sels de ceux-ci, acceptables d'un point de vue pharmaceutique, des procédés pour fabriquer des dérivés de 1,2,4 triazolylaminoaryl(hétéroaryl)sulfonamide, ainsi que des compositions pharmaceutiques contenant des dérivés de 1,2,4 triazolylaminoaryl(hétéroaryl)sulfonamide. Les dérivés de 1,2,4 triazolylaminoaryl(hétéroaryl)sulfonamide selon cette invention présentent une activité d'inhibition de cycle cellulaire et sont par conséquent utilisés pour leur activité anti-prolifération cellulaire (par exemple anticancéreuse).

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