1,3,5-trithian derivatives

Details 1,3,5-trithian derivatives 1,3,5-trithian derivatives

C - Chemistry, Metallurgy

07

D

167/208, 167/242

C07D 341/00 (2006.01) A61K 31/385 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 413/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1296728

25711-484 ABSTRACT OF THE DISCLOSURE A 1,3,5-trithiane derivative represented by the general formula (I): Image wherein R1 is a hydrogen atom, R2 is a hydrogen atom or an imi- dazolyl group, or R2, when taken together with R1, forms a double bond between the carbon atom of the trithiane ring and the one to which R3 and R4 are bonded, R3 is an unsubstituted-phenyl group; a substituted-phenyl group having one or two substituents selected from the group consisting of halogen atoms, C1- to C5-alkyl groups, C1- to C5-haloalkyl groups, C3- to C7-cycloalkyl groups, hydroxyl group, C1- to C5- alkoxy groups (whose alkyl portion is optionally substituted by a morpholino group, an N-substituted- piperazino group having a C1- to C3-alkyl group as the substitu- ent, a C3- to C10-alkoxycarbonyl group, a phenyl group or a halo- phenyl group), C3- to C7-cycloalkoxy groups, phenoxy group (whose phenyl portion is optionally substituted by a halogen atom, a C1- to C5-alkyl group or a C1- to C5- alkoxy group), phenylthio group, phenylsulfinyl group, nitro group, N,N-C2- to C8-dialkylamino groups, morpholino group, imidazolyl group, phenyl group, halo- phenyl groups, phenylalkyl groups and pyridyloxy group; a hetero- aromatic group; a polycyclic fused ring group; a substituted -C1- 25711-484 to C5-alkyl group having a phthalimido-1-yl group or a phenoxy- phenyl group as the substituent, or a halostyryl group, or R3, when taken together with R2, forms a C1- to C9-alkylidene group, R4 is a hydrogen atom; a C1- to C8-alkyl group (which is option- ally substituted by a halogen atom, a C2- to C5-alkoxycarbonyl group, a hydroxycarbonyl group, hydroxy group or a C1- to C5- alkoxy group); a C15- to C20-alkenylene group; hydroxycarbonyl group; C2- to C5 alkoxycarbonyl group, an unsubstituted-phenyl group; a substituted-phenyl group having one or two substituents selected from the group consisting of halogen atoms, C1- to C6- alkyl groups, C1- to C9-haloalkyl groups, C1- to C5- alkylthio groups, C2- to C6-alkoxycarbonyl groups and hydroxycarbonyl group; or a halostyryl group, or R3 and R4, when taken together with the carbon atom to which they are bonded, represent a fluoren-9- ylidene group, each of , m and n is zero or an integer of 1 or 2, and R4 is a group other than phenyl group in the case where R3-is a phenyl group, a pharmaceutical composition containing the same, and a process for producing the same. The compounds may be useful as anti-arteriosclerotic agents and anti-hyperlipemic agents.

542009

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