1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1,...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 401/04 (2006.01) A61K 31/4545 (2006.01) A61P 25/00 (2006.01) C07D 493/10 (2006.01)

Patent

CA 2696948

The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors - subtype 2("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

La présente invention porte sur de nouveaux composés, en particulier sur de nouveaux dérivés de pyridinone selon la Formule (I), dans laquelle tous les radicaux sont tels que définis par les présentes. Les composés selon l'invention sont des modulateurs allostériques positifs de récepteurs métabotropiques de sous-type 2 (=mGluR2 =), qui sont utiles pour le traitement ou la prévention de troubles neurologiques et psychiatriques associé à un dysfonctionnement du glutamate, ainsi que de maladies dans lesquelles le sous-type mGluR2 de récepteurs métabotropiques est mis en jeu. En particulier, de telles maladies sont des troubles du système nerveux central choisis parmi l'anxiété, la schizophrénie, la migraine, la dépression et l'épilepsie. L'invention porte également sur des compositions pharmaceutiques et des procédés pour préparer de tels composés et de telles compositions, ainsi que sur l'utilisation de tels composés pour la prévention et le traitement de maladies dans lesquelles mGluR2 est mis en jeu.

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