C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/22 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/443 (2006.01) A61P 9/00 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2635262
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. The compounds have 3 cyclic groups connected by single bonds, as for example triphenyl, which are attached directly to the ring of formula I or attached at the position B.
La présente invention concerne des composés possédant la structure de la formule I, y compris des sels pharmaceutiquement acceptables de ces composés. Lesdits composés sont des inhibiteurs de la CETP et sont utiles pour augmenter le cholestérol HDL, réduire le cholestérol LDL et pour traiter ou prévenir l'athérosclérose. Ces composés présentent 3 groupes cycliques reliés par des liaisons simples, comme par exemple le triphényle, qui sont attachés directement au cycle de la formule I ou sont attachés à la position B.
Ali Amjad
Chen Yi-Heng
Li Hong
Lu Zhijian
Sinclair Peter J.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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