1,4,5,6-tetrahydropyrazolo-¬3,4-c|-pyridin-7-ones as factor...

Details 1,4,5,6-tetrahydropyrazolo-¬3,4-c|-pyridin-7-ones as factor... 1,4,5,6-tetrahydropyrazolo-¬3,4-c|-pyridin-7-ones as factor...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/415 (2006.01) A61K 31/4162 (2006.01) A61K 31/437 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) C07D 221/00 (2006.01) C07D 231/00 (2006.01)

Patent

CA 2441772

The present application describes 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7- ones of Formula (I) or pharmaceutically acceptable salt forms thereof, wherein ring R is 3-amido or 4-methoxy, R1 is trifluoromethyl or amido, and R2 is aminomethyl, N-methylaminomethyl, and N,N-dimethylaminomethyl. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

La présente invention concerne des 1,4,5,6-tétrahydropyrazolo-[3,4-c]-pyridin-7-ones de formule (I) ou leurs formes salines pharmaceutiquement acceptables. Dans cette formule, le noyau R est 3-amido ou 4-méthoxy, R?1¿ est trifluorométhyle ou amido, et R?2¿ est aminométhyle, N-méthylaminométhyle et N,N-diméthylaminométhyle. Les composés de la présente invention sont utiles comme inhibiteurs des sérine-protéases du type trypsine, et notamment du facteur Xa.

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