C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/08 (2006.01) A61K 31/4995 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2696680
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
Cette invention porte sur de nouveaux dérivés de 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyle et sur leur utilisation dans la fabrication de compositions pharmaceutiques. On a découvert que les composés de l'invention sont des ligands cholinergiques au niveau des récepteurs nicotiniques de l'acétylcholine. En raison de leur profil pharmacologique, les composés de l'invention peuvent être utiles pour le traitement de maladies ou de troubles aussi divers que ceux liés au système cholinergique du système nerveux central (CNS), au système nerveux périphérique (PNS), de maladies ou de troubles liés à la contraction des muscles lisses, de maladies ou de troubles endocriniens, de maladies ou de troubles liés à la neurodégénérescence, de maladies ou de troubles liés à l'inflammation, à la douleur et aux symptômes de sevrage provoqués par la fin de l'abus de substances chimiques.
Christensen Jeppe Kejser
Dyhring Tino
Nielsen Elsebet Østergaard
Olsen Gunnar M.
Peters Dan
Mccarthy Tetrault Llp
Neurosearch A/s
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