C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/228, 260/292
C07D 211/18 (2006.01) A61K 31/445 (2006.01) C07D 211/22 (2006.01) C07D 211/28 (2006.01) C07D 211/32 (2006.01) C07D 405/06 (2006.01)
Patent
CA 1322007
ABSTRACT The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds of the formula: Image wherein Y is H, CO(CH2)nCH3, or SO2(CH2)nCH3 in which n is an integer from 0 to 3; X is CO, CHOH, or C=N-O- A, wherein A is hydrogen or a C1-4 alkyl; R is either selected from the group consisting of halogens, lower alkyl groups, lower alkoxy groups, and hydrogen or R is a divalent substituent and is a 3,4-methylenedioxy or a 3,4-ethylenedioxy substituent; and m is an integer from 1 to 5; or a pharmaceutically acceptable acid addition salt thereof. These compounds are useful as antiarrhythmics, analgesics, and serotonin 5HT2 antagonists.
586190
Carr Albert A.
Dage Richard C.
Koerner John E.
Li Tung
Miller Francis P.
Merrell Dow Pharmaceuticals (canada) Inc.
Osler Hoskin & Harcourt Llp
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