C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/06 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2119755
A novel 1,8-benzo[b]naphthyridine derivative of general formula (I), wherein R is H or a hydroxy, amino or alkylamino radical optionally substituted by amino or hydroxy, or R is dialkylamino of which the alkyl portions may form, with the nitrogen atom, a 5- or 6-membered heterocyclic ring which optionally contains a further heteroatom chosen from nitrogen, oxygen or sulphur, or R is C3-6 cycloalkylamino or an alkanylamino, N-alkyl N-alkanylamino or aminoalkylphenylamino radical; R1 and R2, which are the same or different, are in positions 2 and 3 and represent H, alkyl, C2-4 alkenyl, phenyl, or substituted phenyl, or R1 and R2 are in position 2 and represent alkyl; R3 is H or alkyl, fluoroalkyl, carboxyalkyl, C3-6 cycloalkyl, fluorophenyl, difluorophenyl, alkyloxy or alkylamino; and R4 is H or F, wherein the C1-4 alkanyl and alkyl radicals are linear or branched; stereoisomeric forms thereof or mixtures of these; and salts and hydrated forms thereof. These novel derivatives are useful as antimicrobials.
2119755 9307144 Nouveau dérivé de la benzo[b]naphtyridine-1,8 de formule générale (I) dans laquelle, R est H ou un radical hydroxy, amino, alcoylamino éventuellement substitué par amino ou hydroxy ou R est dialcoylamino dont les parties alcoyle peuvent former avec l'atome d'azote, un hétérocycle à 5 ou 6 chaînons contenant éventuellement un autre hétéroatome choisi parmi l'azote, l'oxygène ou le soufre, ou R est cycloalcoylamino (3 à 6C), ou un radical alcanoylamino, N-alcoyl N-alcanoyl amino ou aminoalcoylphénylamino, R1 et R2 identiques ou différents sont en position 2 et 3 et représentent H, alcoyle, alcényle (2 à 4C), phényle, phényle substitué, ou bien R1 et R2 sont en position 2 et représentent alcoyle, R3 est H ou alcoyle, fluoroalcoyle, carboxyalcoyle, cycloalcoyle contenant 3 à 6 atomes de carbone, fluorophényle, difluorophényle, alcoyloxy ou alcoylamino, et R4 est H ou F, les radicaux alcoyle et alcanoyle (1 à 4C) étant droits ou ramifiés, sous ses formes stéréoisomères ou leurs mélanges ainsi que ses sels et ses formes hydratées. Ces nouveaux dérivés sont utiles comme antimicrobiens.
Bacque Eric
Barreau Michel
Desconclois Jean-Francois
Girard Philippe
Lavergne Marc Pierre
Laboratoire Roger Bellon
Robic
LandOfFree
1,8-benzonaphtyridine derivatives and antimicrobial... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1,8-benzonaphtyridine derivatives and antimicrobial..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,8-benzonaphtyridine derivatives and antimicrobial... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2081337