C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/04 (2006.01) A61K 31/401 (2006.01) A61K 31/4025 (2006.01) A61P 31/12 (2006.01) C07D 207/16 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2503471
Anti-viral agents of Formula (I) wherein: A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C1-6alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or optionally substituted C1-6alkyl; J represents C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl;and salts, solvates and esters thereof; provided that when A is esterified to form -OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl;processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.
Agents antiviraux correspondant à la formule (I) dans laquelle: A représente hydroxy;D représente aryle ou hétéroaryle; E représente hydrogène, alkyle C1-6, aryle, hétéroaryle ou hétérocyclyle; G représente hydrogène ou alkyle C1-6 éventuellement substitué; J représente alkyle C1-6, hétérocyclylalkyle, arylalkyle ou hétéroarylalkyle; et leurs sels, solvates et esters; A est estérifié pour former -OR, et si R est sélectionné entre alkyle, aralkyle, aryloxyalkyle ou aryle à chaîne droite ou ramifiée, R est autre que tert-butyle. L'invention concerne aussi des processus de fabrication, des compositions pharmaceutiques les comprenant et des procédés pour les utiliser dans le traitement de HCV.
Haigh David
Hartley Charles David
Howes Peter David
Jackson Deborah Lynette
Shah Pritom
Glaxo Group Limited
Gowling Lafleur Henderson Llp
LandOfFree
1-acyl-pyrrolidine derivatives for the treatment of viral... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1-acyl-pyrrolidine derivatives for the treatment of viral..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-acyl-pyrrolidine derivatives for the treatment of viral... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1611642