1-heterocyclyl-1,5-dihydro-pyrazolo [3,4-d] pyrimidin-4-one...

Details 1-heterocyclyl-1,5-dihydro-pyrazolo [3,4-d] pyrimidin-4-one... 1-heterocyclyl-1,5-dihydro-pyrazolo [3,4-d] pyrimidin-4-one...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2757231

The invention relates to novel 1,6-disubstituted pyrazolopyrimidinones of formula (I), in which is a tetrahydropyranyl-group and R1 is the group V-W-*, whereby V and W independently of each other may be an aryl group or an heteroaryl group, which independently of each other may optionally be substituted. According to one aspect of the invention the new compounds are for use as medicaments or for the manufacture of medicaments, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. The new compounds are also for the manufacture of medicaments and / or for use in the treatment of e.g. Alzheimer's disease, in particular for cognitive impairment associated with Alzheimer's disease.

L'invention porte sur de nouveaux pyrazolopyrimidinones 1,6-disubstitués de formule (I) dans laquelle Hc est un groupe tétrahydropyranyle et R1 est le groupe V-W-*, où V et W peuvent indépendamment être un groupe aryle ou un groupe hétéroaryle qui peuvent indépendamment être facultativement substitués. Selon un aspect de l'invention, les nouveaux composés sont destinés à être utilisés en tant que médicaments ou pour la fabrication de médicaments, en particulier de médicaments pour le traitement d'états pathologiques concernant des déficits de perception, de concentration, d'apprentissage ou de mémoire. Les nouveaux composés sont également destinés à la fabrication de médicaments et/ou destinés à une utilisation dans le traitement de, par exemple, la maladie d'Alzheimer, en particulier de dysfonctionnements cognitifs associés à la maladie d'Alzheimer.

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