C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/272
C07D 461/00 (2006.01) A61K 31/585 (2006.01)
Patent
CA 1199637
Abstract The invention relates to new polycyclic compounds substituted on the A-ring. More particularly, the invention concerns new polycyclic compounds of the general formula /I/ Image /I/ wherein R1 is methoxy or halogen and R2 is hydrogen; or R1 is hydrogen and R2 is halogen and acid addition salts thereof. According to another aspect of the invention the new compounds of the general formula /I/ are prepared by reacting compounds of the general formula /II/ -2- Image /II/ wherein R1 and R2 are as defined above, with 3,4,5- -trimethoxy-benzoic acid or a derivative thereof capable of acylation. According to still another aspect of the invention there are provided pharmaceutical compositions comprising as an active ingredient a compound of the general formula /1/. The compounds have phosphodiesterase inhibiting activity.
395305
Forgach Lilla
Kalaus Gyorgy
Karpati Egon
Kiraly Arpad
Kiraly Gyongyver
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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