C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) C07K 16/00 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2706476
The invention provides anti-14-3-3 eta antibodies that specifically bind to the human 14-3-3 eta protein isoform in its natural configuration while exhibiting selectivity over human 14-3-3 alpha, beta, delta, epsilon, gamma, tau, and zeta protein isoforms. Methods, kits and pharmaceutical compositions comprising said specific anti-14-3-3 eta antibodies are further provided for the diagnosis and treatment of arthritis.
La présente invention concerne des anticorps anti-14-3-3 êta qui se lient spécifiquement à l'isoforme de la protéine 14-3-3 êta humaine dans sa configuration naturelle tout en présentant une sélectivité vis-à-vis des isoformes protéiques 14-3-3 alpha, bêta, delta, epsilon, gamma, tau, et zeta humaines. L'invention concerne en outre des procédés, des trousses et des compositions pharmaceutiques contenant lesdits anticorps anti-14-3-3 êta spécifiques pour le diagnostic et le traitement de l'arthrite.
Marotta Anthony
Smart & Biggar
The University Of British Columbia
LandOfFree
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