C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/235.01
C07C 61/08 (2006.01) C07C 29/09 (2006.01) C07C 29/147 (2006.01) C07C 29/36 (2006.01) C07C 29/42 (2006.01) C07C 29/62 (2006.01) C07C 45/30 (2006.01) C07C 45/45 (2006.01) C07C 45/62 (2006.01) C07C 47/293 (2006.01) C07C 47/30 (2006.01) C07C 49/293 (2006.01) C07C 49/433 (2006.01) C07C 49/443 (2006.01) C07C 51/09 (2006.01) C07C 51/353 (2006.01) C07C 51/38 (2006.01) C07C 61/04 (2006.01) C07C 405/00 (2006.01) C07F 1/08 (2006.01)
Patent
CA 1191132
15-DEOXY-16-HYDROXY PROSTAGLANDINS ABSTRACT Analogues of PGE1 having the structural formula, Image in which R1 and R2 are hydrogen; R3 is selected from the group consisting of hydrogen or methyl, or together with R4 is a methylene or a lower alkylated methylene chain of 4 to 5 carbon atoms such that a cycloalkyl or a lower alkylated cycloalkyl of 6 to 7 carbon atoms inclusive is formed, or together with R4 is a bicycloalkyl or bicycloalkenyl moiety having the formula: Image such that a bicycloalkyl or bicycloalkenyl compound is formed, wherein p is an integer having a value of from 0 to 1 and q is an integer having a value of from 2 to 3 and wherein the double bond of such bicycloalkenyl is in the q bridge; R4 is hydrogen or methyl or together with R3 forms a cycloalkyl or bicycloalkyl or bicycloalkenyl as defined above or together with R5 is a methylene chain of 3 carbon atoms such that a cycloalkyl of 4 carbon atoms inclusive is formed; R5 is hydrogen or methyl or together with R4 forms a cycloalkyl as defined above; and R6 is hydrogen or a straight-chain alkyl of 3 carbon atoms.
322181
Biddlecom William G.
Kluender Harold C.
Woessner Warren D.
Miles Laboratories Inc.
Osler Hoskin & Harcourt Llp
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