[1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine...

Details [1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine... [1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2590961

The invention provides compounds of formula (I) and methods for inhibition of kinases, more specifically p70S6 kinases, and more preferably p70S6, Akt-1 and Akt-2 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

L'invention concerne des composés de formule I et des méthodes d'inhibition des kinases, plus précisément des kinases p70S6, et idéalement des kinases p70S6, Akt-1 et Akt-2. L'invention porte sur des composés de modulation de l'activité enzymatique des protéines kinases pour moduler les activités cellulaires, telles que la prolifération, la différenciation, la mort cellulaire programmée, la migration, l'invasion chimique et le métabolisme. Les composés de l'invention inhibent, régulent et/ou modulent les voies de transduction du signal du récepteur de la kinase associées aux changements d'activités cellulaires susmentionnés. L'invention porte sur des compositions qui contiennent ces composés et sur leurs méthodes d'utilisation pour traiter des maladies et des états dépendants des kinases.

Affiliated with

Also associated with

Rating

[1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with [1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and [1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1653752