2- ( (2, 3-dihydroxypropyl) aminomethyl) chromane...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 311/58 (2006.01) A61K 31/353 (2006.01) A61K 31/403 (2006.01) A61K 31/4192 (2006.01) A61P 13/00 (2006.01) A61P 29/00 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2548922

This invention relates to chroman derivatives of formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations. The chroman derivatives of the present invention have an excellent activity as BETA 3 antagonists and are useful for the prophylaxis and treatment of diseases associated with BETA 3 activity, in particular for the treatment of urological disorder or disease, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; and inflammatory disorders, such as asthma and COPD.

L'invention concerne des dérivés de chromane représentés par la formule (I) ainsi que des sels desdits dérivés qui sont utiles en tant qu'ingrédients actifs de préparations pharmaceutiques. Les dérivés de chromane selon l'invention présentent une excellente activité en tant qu'antagonistes BETA 3 et sont utiles pour la prophylaxie et le traitement de maladies associées à l'activité de BETA 3, notamment pour le traitement de troubles ou de maladies urologiques, tels que l'hyperactivité du détrusor (vessie hyperactive), l'incontinence urinaire, l'hyperactivité neurogène du détrusor (hyperflexie du détrusor), l'hyperactivité idiopathique du détrusor (instabilité du détrusor), l'hyperplasie prostatique bénigne et les symptômes des voies urinaires inférieures ; et des troubles inflammatoires, tels que l'asthme et la bronchopneumopathie chronique obstructive.

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