2',2'-difluoronucleosides

Details 2',2'-difluoronucleosides 2',2'-difluoronucleosides

C - Chemistry, Metallurgy

07

H

260/229.4

C07H 19/073 (2006.01) C07D 307/33 (2006.01)

Patent

CA 1330988

ABSTRACT The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleo- sides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enantiomeric mixture of erythro and threo lactones in crystalline form. Also provided is a process for producing 2'-deoxy-2',2'- difluoronucleosides in about a 1:1 .alpha./.beta. anomeric ratio, and processes for selectively isolating .beta.-2'-deoxy-2',2'- difluorocytidine, or an organic or inorganic acid addi- tion salt thereof, from the 1:1 .alpha./.beta. mixture.

616612

Affiliated with

Also associated with

Rating

2',2'-difluoronucleosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2',2'-difluoronucleosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2',2'-difluoronucleosides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1214563