C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01)
Patent
CA 2563639
The present invention is directed to 2, 4, 6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer~s disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta- secretase enzyme is involved.
La présente invention porte sur des composés dérivés de pyridyle substitués aux positions 2, 4, 6 qui sont des inhibiteurs de l'enzyme bêta-sécrétase et qui sont utiles dans le traitement de maladies telles que la maladie d'Alzheimer dans lesquelles est impliquée ladite enzyme. L'invention porte également sur des compositions pharmaceutiques comprenant ces composés et sur leur utilisation dans le traitement de ces maladies dans lesquelles est impliquée l'enzyme bêta-sécrétase.
Barrow James C.
Coburn Craig A.
Mcgaughey Georgia B.
Nantermet Philippe G.
Rajapakse Hemaka A.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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