2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives...

Details 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives... 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives...

C - Chemistry, Metallurgy

07

C

C07C 229/58 (2006.01) A61K 31/195 (2006.01) C07C 215/68 (2006.01) C07C 237/30 (2006.01) C07C 237/32 (2006.01) C07C 237/36 (2006.01) C07C 243/28 (2006.01) C07C 243/38 (2006.01) C07C 311/44 (2006.01) C07D 213/40 (2006.01) C07D 257/04 (2006.01) C07D 295/12 (2006.01) C07D 295/155 (2006.01) C07D 295/32 (2006.01) C07D 333/20 (2006.01)

Patent

CA 2290509

Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, and Z is COOR7, tetrazolyl, CONR6R7, or CH2OR7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.

On décrit des dérivés d'acide benzoïque phénylamino, de benzamide et d'alcool benzylique de formule (I). Dans la formule R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, et R¿6? représentent hydrogène ou des groupes substituants tel que alkyle, R¿7? représentant hydrogène ou un radical organique et Z représentant COOR¿7?, tétrazolyle, CONR¿6?R¿7? ou CH¿2?OR¿7?. Ces dérivés sont de puissants inhibiteurs de MEK et en tant que tels ils sont efficaces dans le traitement du cancer et d'autres maladies proliférantes tels que l'inflammation, le psoriasis et la resténose ainsi que dans le traitement des accidents cérébraux vasculaires, de l'insuffisance cardiaque et des troubles liés à l'immonodéficience.

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