2-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-3-phenyl pyrazines...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/12 (2006.01) A61K 31/497 (2006.01) A61P 25/06 (2006.01) A61P 25/22 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2684563

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)= or N=, provided that at least one of A and B is -N=, n is 1-3, m is 0-3, and R14 are as defined herein.

La présente invention concerne des composés antagonistes de récepteur 5-HT7 sélectifs de formule I et leur utilisation dans le traitement de la migraine, de la douleur persistante et de l'anxiété : où A et B sont chacun indépendamment C(H)= ou N=, à condition qu'au moins l'un de A et de B soit -N=, n vaut 1 à 3, m vaut 0 à 3, et R14 est tel que défini ici.

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