2',5'-phosphorothioate oligoadenylates and antiviral uses...

Details 2',5'-phosphorothioate oligoadenylates and antiviral uses... 2',5'-phosphorothioate oligoadenylates and antiviral uses...

C - Chemistry, Metallurgy

07

H

167/163, 167/202

C07H 21/02 (2006.01) A01N 63/00 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01)

Patent

CA 1339953

Optically active compounds of the formula Image wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internucleotide phosphorothioate linkages is of the Sp configuration possess increased antiviral activity and/or metabolic stability.

580426

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