2,6-bis(chloromethyloxy-carbonyloxymethyl)-pyridine and a...

Details 2,6-bis(chloromethyloxy-carbonyloxymethyl)-pyridine and a... 2,6-bis(chloromethyloxy-carbonyloxymethyl)-pyridine and a...

C - Chemistry, Metallurgy

07

D

260/297.95

C07D 213/55 (2006.01) C07D 213/30 (2006.01)

Patent

CA 1304091

- 10 - 2,6-BIS(CHLOROMETHOXY-CARBONYLOXYMETHYL)PYRIDINE AND A PROCESS FOR PREPARING SAME A b s t r a c t The invention relates to the novel 2,6-bis(chlo- romethyloxy-carbonyloxymethyl)pyridine of the formula (I) Image (I) as well as a process for the preparation of this compound, which is a useful intermediate in the preparation of the anti-atherosclerotic 2,6-bis(hydroxy- methyl)pyridine bis(N-methylcarbamate) (pyridinol- carbamate) and other drugs. According to the invention, the compound of the formula (I) is prepared by reacting 2,6-bis(hyd- roxymethyl)pyridine of the formula (II) Image (II) - 11 - with chloromethyl chloroformate of the formula (III) Image (III) in a polar-aprotic, water-immiscible organic solvent, in the presence of a basic substance between about -30 °C and +10 °C.

545124

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