2, 6-dinitrogen-containing substituted purine derivatives,...

Details 2, 6-dinitrogen-containing substituted purine derivatives,... 2, 6-dinitrogen-containing substituted purine derivatives,...

C - Chemistry, Metallurgy

07

D

C07D 473/16 (2006.01) A61K 31/52 (2006.01) A61K 31/7076 (2006.01) A61P 35/00 (2006.01) C07H 19/16 (2006.01) C07H 19/173 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2684638

The present invention provides 2, 6-dinitrogen-containing substituted purine compounds of formula (A) or their salts or their solvates or the solvates of their salts, as well as pharmaceutical compositions containing such compounds. The compounds of the invention have the characteristic of lower toxicity, broad anticancer spectrum, higher anticancer activity, good stability and the like. The compounds are useful for the manufacture of an antitumor medicament. The present invention also provides a process for preparing these compounds.

La présente invention concerne des composés purine substitués contenant 2, 6 diazote représentés par la formule (A) ou leurs sels ou leurs solvates ou les solvates de leurs sels, ainsi que des compositions pharmaceutiques contenant ces composés. Les composés de l'invention présentent la caractéristique d'une toxicité moindre, un large spectre anticancéreux, une activité anticancéreuse élevée, une bonne stabilité et d'autres caractéristiques similaires. Ces composés conviennent pour la fabrication d'un médicament antitumoral. La présente invention concerne aussi un processus de préparation de ces composés.

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