[2 , 6] naphthyridines useful as protein kinase inhibitors

Details [2 , 6] naphthyridines useful as protein kinase inhibitors [2 , 6] naphthyridines useful as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2682340

The present invention provides a compound of formula I: (formula I) said compound is inhibitor of selective subset of kinases belonging to the AGC or calmodulin kinase family, such as for example MARK1/2/3, PKD-1/2/3, PKN-1/2, CDK-9, CaMKII, ROCK-I/II, inhibitors of histone deacetylase (HDAC) phosphorylation, or inhibitors of other kinases. Finally, the present invention also provides a pharmaceutical composition.

L'invention concerne un composés de formule I : (formule I), utile en tant qu'inhibiteur d'un sous-ensemble sélectif de kinases appartenant à la famille des kinases AGC ou calmoduline, telles que MARK1/2/3, PKD-1/2/3, PKN-1/2, CDK-9, CaMKII, ROCK-I/II, inhibiteurs de la phosphorylation d'histone désacétylase (HDAC) ou inhibiteurs d'autres kinases. L'invention concerne également une composition pharmaceutique associée.

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