C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/14 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 3/06 (2006.01) C07D 239/95 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2498655
The present invention relates to 2-amino-4-oxo-quinazolines according to the general formula (1), which bind to the LXR receptors and act as agonists and antagonists of the LXR receptors. The invention further relates to the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and the production of medicaments using said compounds. In particular the compounds are useful in the treatment of hypercholesterolemia, obesity or other diseases associated with elevated lipoprotein (LDL) levels.
L'invention concerne des 2-amino-4-oxo-quinazolines de formule générale (I) qui se fixent sur les récepteurs LXR et servent d'agonistes et d'antagonistes de ces récepteurs LXR. Cette invention se rapporte en outre au traitement de maladies et/ou d'états, par fixation de ces composés sur ledit récepteur nucléaire, ainsi qu'à la production de médicaments au moyen desdits composés. En particulier, les composés selon l'invention peuvent être utilisés pour traiter l'hypercholestérolémie, l'obésité et d'autres maladies associées à des niveaux élevés de lipoprotéine (LDL).
Bauer Ulrike
Blume Beatrix
Deuschle Ulrich
Hermann Kristina
Kober Ingo
Heenan Blaikie Llp
Phenex Pharmaceuticals Ag
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