2-aminopyridine compounds and medical use thereof

Details 2-aminopyridine compounds and medical use thereof 2-aminopyridine compounds and medical use thereof

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) A61K 31/4409 (2006.01) A61K 31/443 (2006.01) A61K 31/4436 (2006.01) A61K 31/444 (2006.01) A61K 31/455 (2006.01) A61P 1/00 (2006.01) A61P 1/10 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 7/10 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 19/10 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 43/00 (2006.01) C07D 213/80 (2006.01) C07D 213/85 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2417846

2-Aminopyridine compounds of the general formula (I) and salts thereof, exhibiting excellent adenosine receptor (A1, A2a, or A2b receptor) antagonism wherein R1 is cyano, carboxyl, or optionally substituted carbamoyl; R2 is hydrogen, hydroxyl, optionally substituted C1-6 alkoxy, an optionally substituted C6-14 aromatic carbocyclic group, or an optionally substituted 5- to 14-membered aromatic heterocyclic group; and R3 and R4 are each independently an optionally substituted C6-14 aromatic carbocyclic group, a 5- to 14-membered nonaromatic heterocyclic group, a 5- to 14-membered aromatic heterocyclic group, or the like.

L'invention concerne des composés 2-aminopyridine de la formule générale (I) et leurs sels, qui présentent un excellent antagonisme du récepteur de l'adénosine (récepteur A¿1?, A¿2? ou A¿2b?). R?1¿ représente cyano, carboxyle ou carbamoyle éventuellement substitué; R?2¿ représente hydrogène, hydroxyle, C¿1-6? alcoxy éventuellement substitué, C¿6-14? groupe carboxylique aromatique éventuellement substitué ou un groupe hétérocyclique aromatique de 5 à 14 éléments éventuellement substitué, R?3¿ et R?4¿ représentant chacun individuellement un groupe carbocyclique aromatique éventuellement substitué, un groupe hétérocyclique non aromatique de 5 à 14 éléments, un groupe hétérocyclique aromatique de 5 à 14 éléments, ou analogues.

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