2-benzothiazolyl tetrazolium salt indicators

C - Chemistry – Metallurgy – 07 – D

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C07D 417/04 (2006.01) C07D 417/14 (2006.01) G01N 31/22 (2006.01) G01N 33/52 (2006.01)

Patent

CA 2049230

2-Benzothiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a calorimetric response on a reagent carrier matrix is measured by reflectance.

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