2 .beta., 19-ethylene bridged steroids as aromatase inhibitors

Details 2 .beta., 19-ethylene bridged steroids as aromatase inhibitors 2 .beta., 19-ethylene bridged steroids as aromatase inhibitors

C - Chemistry, Metallurgy

07

J

C07J 53/00 (2006.01) A61K 31/565 (2006.01)

Patent

CA 2056638

The present invention is directed to a group of androstane compounds which contain an ethylene radical bridging the 2- and 19-positions. These compounds are useful as aromatase inhibitors and they are prepared by the cyclization of a 19-[2-(4-toluenesulfonyloxy)ethyl]androst- 4-ene-3,17-dione using a strong base.

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