2-cyano-pyrimidines and -triazines as cysteine protease...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61P 19/10 (2006.01) C07D 239/34 (2006.01)

Patent

CA 2615516

The invention relates to compounds of the formula (I) and salts thereof, to a process for their manufacture, to their use in the treatment of (especially cysteine protease, such as UCH-L3- and/or USP-2 dependent) diseases or for the manufacture of pharmaceutical formulations against these diseases, methods of treatment of warm-blooded animals comprising administering the compounds and/or their salts to said animals and pharmaceutical preparations, especially for the treatment of the diseases, comprising said compounds and/or salts.

L'invention concerne des composés représentés par la formule (I), ainsi que les sels de ceux-ci, un procédé de préparation de ces composés, leur utilisation pour le traitement de maladies (en particulier de maladies dépendantes des cystéine protéases telles que UCH-L3- et/ou USP-2), ou pour la préparation de compositions pharmaceutiques destinées à traiter ces maladies, des méthodes de traitement d'animaux à sang chaud consistant à administrer les composés et/ou leurs sels auxdits animaux, et des préparations pharmaceutiques, en particulier des préparations destinées au traitement des maladies, contenant lesdits composés et/ou sels.

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