2-cyanopyrrolidinecarboxamide compound

Details 2-cyanopyrrolidinecarboxamide compound 2-cyanopyrrolidinecarboxamide compound

C - Chemistry, Metallurgy

07

D

C07D 471/08 (2006.01) A61K 31/4025 (2006.01) A61P 3/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2543533

A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein X1 and X2 each is independently lower alkylene; X3 is =CH2, =CHF or =CF2; R1 is substituent, R2 and R3 each is independently H or lower alkyl; n is 0, 1, 2, 3 or 4.] having the activity inhibiting DPP-IV activity. They are therefore useful in the treatment of conditions mediated by DPP-IV, such as NIDDM.

L'invention concerne un composé de formule (I) ou un sel acceptable sur le plan pharmaceutique de celui-ci, dans laquelle : X?1¿ et X?2¿ représentent chacun indépendamment alkylène inférieur ; X?3¿ représente =CH2, =CHF ou =CF2 ; R?1¿ est un substituant ; R?2¿ et R?3¿ représentent chacun indépendamment H ou alkyle inférieur ; n vaut 0, 1, 2, 3 ou 4. Ce composé présente une activité inhibant l'activité DPP-IV. Les composés de l'invention sont utiles dans le traitement d'états dont la médiation est assurée par DPP-IV, de type NIDDM.?¿

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