2-halo-6-o-substituted ketolide derivatives

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 17/08 (2006.01) A61K 31/70 (2006.01) A61K 31/7048 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2307788

Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

La présente invention concerne dérivés kétolide à substitution 2-halo-6-O, certains de leurs sels pharmaceutiquement admis, et certains esters de ces sels présentant une activité antibactérienne, tous produits représentés par la formule générale (I) ou (II). L'invention concerne également, d'une part des compositions comprenant une quantité thérapeutiquement efficace d'un composé de l'invention en association avec un vecteur pharmaceutiquement admis, et d'autre part un traitement d'infections bactériennes consistant en l'administration à un mammifère d'une composition comprenant une quantité thérapeutiquement efficace d'un composé de l'invention. L'invention concerne enfin des procédés d'élaboration de ces produits.

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