2-morpholino-4-pyrimidone compound

Details 2-morpholino-4-pyrimidone compound 2-morpholino-4-pyrimidone compound

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/5377 (2006.01) A61P 25/28 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2578434

A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein X represents CH or N; 1 represents a C1-C12 alkyl; R2 represents a hydrogen atom, or the like; R' represents a C1-C6 alkyl or the like; q represents 0 or an integer of 1 to 7; Y represents a C1-C6 alkyl or the like; p represents 0 or an integer of 1 to 5; R represents a 2,3-dihydroindolyl or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

L'invention concerne un composé de formule (I), un isomère optiquement actif de celui-ci ou un sel pharmaceutiquement acceptable de celui-ci: (I), où X représente CH ou N; R1 signifie un alkyle C1-C12; R2 désigne un atome d'hydrogène ou similaire; R' représente un alkyle C1-C6 ou similaire; q signifie 0 ou un nombre entier de 1 à 7; Y désigne un alkyle C1-C6 ou similaire; p représente 0 ou un nombre entier de 1 à 5; R signifie un 2,3-dihydro-indolyle ou similaire. Ce composé sert dans le traitement préventif et/ou thérapeutique d'une maladie causée par l'hyperactivité de la tau protéine kinase 1 telle que les maladies neurodégénératives (par ex. la maladie d'Alzheimer).

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