2-oxo-1,3-oxazolo¬4,5|quinolines useful as anti-allergy agents

Details 2-oxo-1,3-oxazolo¬4,5|quinolines useful as anti-allergy agents 2-oxo-1,3-oxazolo¬4,5|quinolines useful as anti-allergy agents

C - Chemistry, Metallurgy

07

D

167/227, 260/273

C07D 471/04 (2006.01) C07D 215/28 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 1246578

ABSTRACT OF THE DISCLOSURE New quinoline compound, and the corresponding 1,2; 1,3; and 1,4-benzodianes, the quinoline compounds being of the formula Image and salts thereof, wherein R1 and R2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl, Y is oxygen, sulfur, nitrogen or R3N wherein R3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, ar- alkyl, acyl, aminoalkyl, or carboxylalkyl, Z is oxygen, sulfur or nitrogen, X is cyano, carbalkoxyl, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, and m is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or as intermediates in tha preparation of compounds useful for treating asthma.

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