C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/395 (2006.01) C07C 311/29 (2006.01) C07D 207/48 (2006.01) C07D 211/54 (2006.01) C07D 223/12 (2006.01) C07D 241/04 (2006.01) C07D 243/08 (2006.01) C07D 295/13 (2006.01) C07D 295/26 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 453/02 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2520225
The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.
La présente invention a trait à un dérivé de benzènesulfonamide de formule (I), utile en tant que principe actif de préparations pharmaceutiques. Les dérivés de benzènesulfonamide de la présente invention ont une activité antagoniste de CCR3 (récepteur de chimiokine de type CC), et peut être utilisé pour la prophylaxie et le traitement de maladies associées à l'activité de CCR3, notamment pour le traitement de l'asthme, de la dermatite atopique, de la rhinite allergique et d'autres troubles inflammatoires/immunologiques. Dans ladite formule (I) : X représente O ou S ; R?4¿ représente les autres substituants tels que définis dans la revendication 1.
Bacon Kevin
Fukushima Keiko
Hashimoto Kentaro
Li Yingfu
Marumo Makiko
Actimis Pharmaceuticals Inc.
Axikin Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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