C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/06 (2006.01) A61K 31/165 (2006.01) A61K 31/341 (2006.01) A61P 25/00 (2006.01) C07D 307/52 (2006.01)
Patent
CA 2629065
2-Phenylethylamino substituted carboxamide derivatives of formula (I); wherein J, W, R, R0 R1, R2, R3, and R4 have the meanings as defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing alleviating and curing a wide range of pathologies, including neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urology, and gastrointestinal diseases where the above mechanisms have been described as playing a pathological role, are described.
La présente invention a pour objet des dérivés de carboxamide 2-phényléthylamino substitués de formule (I) ; où J, W, R, R0 R1, R2, R3 et R4 ont les valeurs définies dans la description ainsi que les sels de qualité pharmaceutique desdits dérivés, les préparations pharmaceutiques les contenant au titre de principe actif et leur utilisation en tant que modulateurs du canal sodium et/ou calcium pouvant être employés dans la prévention, le soulagement et la guérison d'une large gamme de pathologies, y compris des maladies neurologiques, psychiatriques, cardio-vasculaires, inflammatoires, ophtalmiques, urologiques et gastro-intestinales, les mécanismes ci-dessus ayant été décrits comme jouant un rôle pathologique.
Caccia Carla
Faravelli Laura
Moriggi Ermanno
Napoletano Mauro
Restivo Alessandra
Newron Pharmaceuticals S.p.a.
Robic
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