2-piperazino-pteridines, process for preparing them and...

Details 2-piperazino-pteridines, process for preparing them and... 2-piperazino-pteridines, process for preparing them and...

C - Chemistry, Metallurgy

07

D

167/208, 260/242

C07D 475/08 (2006.01) A61K 31/505 (2006.01) A61K 31/55 (2006.01)

Patent

CA 1337813

The invention relates to new pteridines of general formula Image (I) wherein R4 represents a trimethyleneimino, pyrrolidino, piperidino, hexamethyleneimino or heptamethyleneimino group, R6 represents a fluorine, chlorine or bromine atom and R7 represents a phenylalkylamino, N-alkyl- phenylalkylamino, phenylamino or N-alkyl-phenylamino group, whilst the above-mentioned phenyl nuclei may in each case be mono- or di-substituted by fluorine, chlorine or bromine atoms or by methyl or methoxy groups, and the acid addition salts thereof which have valuable pharmacological properties, particularly antithrombotic and metastasis-inhibiting effects and an inhibiting effect on tumour growth. The new compounds may be prepared by methods known per se.

552565

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