2-pyridyl and 2-pyrimidyl cycloalkylene amide compounds as...

Details 2-pyridyl and 2-pyrimidyl cycloalkylene amide compounds as... 2-pyridyl and 2-pyrimidyl cycloalkylene amide compounds as...

C - Chemistry, Metallurgy

07

D

C07D 213/65 (2006.01) A61K 31/4418 (2006.01) A61K 31/4545 (2006.01) A61P 25/00 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2510322

This invention provides a compound of the Formula (I), wherein R1 represents Formula (II), wherein R5 represents a hydroxy group or the like; R6 represents a hydrogen atom or the like. Z represents a carbon or a nitrogen atom: R2 represents a hydrogen atom or the like: R3 represents a hydrogen or the like: A represents a cycloalkylene or the like: X represents a covalent bond or the like: R4 represents an aryl or the like. These compounds are useful for the treatment of disease conditions caused by overactivation of NMDA NR2B receptor such as pain, or the like in mammals. This invention also provides a pharmaceutical composition comprising the above compound.

L'invention concerne un composé de formule (I), dans laquelle R?1¿ représente le groupe (II), R?5¿ représentant un groupe hydroxy ou similaire, R?6¿ un atome d'hydrogène ou similaire et Z un atome de carbone ou d'azote, R?2¿ représente un atome d'hydrogène ou similaire, R?3¿ représente un atome d'hydrogène ou similaire, A représente un groupe cycloalkylène ou similaire, X représente une liaison covalente ou similaire et R?4¿ représente un groupe aryle ou similaire. Les composés de ce type sont utiles pour traiter des états pathologiques dus à une suractivation du récepteur NMDA NR2B, tels que la douleur ou similaire, chez des mammifères. L'invention concerne également une composition pharmaceutique comprenant ledit composé.

Affiliated with

Also associated with

Rating

2-pyridyl and 2-pyrimidyl cycloalkylene amide compounds as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-pyridyl and 2-pyrimidyl cycloalkylene amide compounds as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-pyridyl and 2-pyrimidyl cycloalkylene amide compounds as... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2066898