2-(tetrazol-5-yl)-1,1'-biphenyl derivatives, their...

Details 2-(tetrazol-5-yl)-1,1'-biphenyl derivatives, their... 2-(tetrazol-5-yl)-1,1'-biphenyl derivatives, their...

C - Chemistry, Metallurgy

07

D

C07D 257/04 (2006.01) C07D 403/00 (2006.01) C07D 405/10 (2006.01) C07F 7/10 (2006.01) C07F 7/22 (2006.01)

Patent

CA 2086364

ABSTRACT Compounds corresponding to the formula (I) Image (I) in which X represents dibromomethyl, formyl, (C1-4)alkyl, or a group CH(OR5)2 or CH(OH)OR5, wherein the or each R5 is hydrogen (C1-3) alkyl or the two R5's in the case of CH(OR5)2 are linked to provide a 1,3-dioxolane or 1,3-dioxane ring, and Y represents hydrogen, 1,1-dimethylethyl, triphenylmethyl, trimethylstannyl, tributylstannyl, (1,1- dimethylethyl)dimethylsilyl, (1,1- dimethylethyl)diphenylsilyl, 2-cyanoethyl, or a group CH2OR6 wherein R6 is methyl, phenylmethyl, 1,1- dimethylethyl, 2,2,2-trichloroethyl, benzyloxycarbonyl or 2,2,2-trichloroethyloxycarbonyl, Y being in position 1 or 2 on the tetrazole ring. The compounds of formula (I) are useful as intermediates in the synthesis of compounds possessing therapeutic activity.

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