20-methyl-substituted vitamin d derivatives

Details 20-methyl-substituted vitamin d derivatives 20-methyl-substituted vitamin d derivatives

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01)

Patent

CA 2125476

New 20-methyl-substituted vitamin D derivatives have general formula (3), in which R1 is a hydrogen atom, a hydroxyl group or an alkanoyloxyl group with 1 to 12 carbon atoms or a benzoyloxyl group, R2 is a hydrogen atom or an alkanoyl group with 1 to 12 carbon atoms or a benzoyl group; and R3 is saturated or unsaturated, straight-chain or branched-chain hydrocarbon residue with up to 18 C atoms, possibly interrupted and/or substituted by one or several carbocyclic structures (C3-10-cycloalkyl or cycloakenyl residues, the latter having up to 2 double bonds), possibly substituted by one or several hydroxyl, oxo, amino groups and/or by one or several halogen atoms, possibly having one or several oxygen, sulphur and/or nitrogen (as (a)) atoms as chaining members in the hydrocarbon residues. Also disclosed is a process for preparing the same. These new compounds have strongly improved induction of cell differentiation (HL- 60), with respect to calcitriol, and are suitable for preparing medicaments.

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