C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/08 (2006.01) A61K 31/18 (2006.01) A61P 11/00 (2006.01) C07C 311/09 (2006.01) C07C 311/13 (2006.01) C07C 311/14 (2006.01) C07C 311/21 (2006.01) C07C 311/29 (2006.01) C07D 277/46 (2006.01) C07D 333/34 (2006.01)
Patent
CA 2649794
The present invention relates to novel (2R)-2-phenylpropanamides bearing a 4-sulfonylamino substituent on the 4 position of the phenyl group and to pharmaceutical compositions containing them, which are used as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells, and which are useful in the treatment of various ELR+CXC chemokine-mediated disorders. In particular, the compounds of the invention are useful in the treatment and control of specific CXCR2 dependent pathologies such as BOS, COPD, angiogenesis and melanoma.
La présente invention concerne de nouveaux (2R)-2-phénylpropanamides portant un substituant 4-sulfonylamino sur la position 4 du groupe phényle ainsi que des compositions pharmaceutiques les contenant, qui sont utilisés en tant qu'inhibiteurs de la chimiotaxie de cellules polymorphonucléées et mononucléées, et qui sont utiles dans le traitement de divers troubles médiés par les chimiokines ELR+ CXC. En particulier, les composés de l'invention sont utiles dans le traitement et la lutte contre des pathologies dépendantes de récepteurs CXCR2 spécifiques telles que le BOS, la BPCO, l'angiogénèse et le mélanome.
Allegretti Marcello
Aramini Andrea
Bertini Riccardo
Bizzarri Cinzia
Cesta Maria Candida
Dompe Pha.r.ma S.p.a.
Kirby Eades Gale Baker
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