(2s)-(5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]...

Details (2s)-(5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]... (2s)-(5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]...

A - Human Necessities

61

K

167/224, 260/296

A61K 31/495 (2006.01) C07D 213/75 (2006.01) C07D 215/227 (2006.01) C07D 471/04 (2006.01)

Patent

CA 1339134

The (2S)-(-)isomer of (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4- b]pyrazin-7-yl)carbamic acid, ethyl ester is significantly more potent than either the (2R)-(+)-isomer or the (R,S)-(~)-racemic mixture in inhibiting mitotic cell division of L1210 leukemia cells. The compound, pharmaceutical compositions containing the compound, and a method of ameliorating cancer diseases in mammals are disclosed.

595096

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