3, 10, and 12a substituted tetracycline compounds

Details 3, 10, and 12a substituted tetracycline compounds 3, 10, and 12a substituted tetracycline compounds

C - Chemistry, Metallurgy

07

C

C07C 237/26 (2006.01) A61K 31/65 (2006.01) A61P 25/28 (2006.01) C07C 255/59 (2006.01) C07C 309/77 (2006.01) C07D 317/60 (2006.01)

Patent

CA 2492273

The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

L'invention porte sur de nouveaux composés de tétracycline substituée en 3, 10, et/ou 12a pouvant traiter de nombreux états sensibles aux composés de tétracycline, tels que les infections bactériennes et les néoplasmes, et servir dans d'autres applications connues des composés de minocycline et de tétracycline, telles que le blocage de l'efflux de tétracycline et la modulation de l'expression génique.

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