3(2h)-pyridazinone derivatives and pharmaceutical...

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 405/12 (2006.01) A61K 31/501 (2006.01) C07D 319/20 (2006.01)

Patent

CA 2222724

The invention relates to R-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]- 3(2H)-pyridazinone of formula (1), and to S-2-[3-([1,4)benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazinone of formula (2), and to acid-addition salts thereof as well as pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for the preparation of the above compounds. The new starting compounds of formulae (4) and (5) are also involved in the scope of the invention. The compounds according to the invention possess .alpha.1- and .alpha.2-adrenoceptor antagonistic effects and urogenital selectivity. Thus, they are useful for the treatment of the benign prostate hyperplasia.

L'invention se rapporte aux composés R-2-[3-([1,4]benzodioxan-2-ylméthylamino)-1-propyl]-3(2H)-pyridazinone de formule (1), et S-2-[3-([1,4]benzodioxan-2-ylméthylamino)-1-propyl]-3(2H)-pyridazinone de formule (2), ainsi qu'aux sels d'addition d'acide desdits composés et aux compositions pharmaceutiques à base de ces composés. On décrit aussi un procédé relatif à l'élaboration de ces composés. Par ailleurs, le champ de l'invention s'étend aux nouveaux composés de départ correspondant aux formules (4) et (5). Les composés considérés sont des antagonistes du récepteur alpha 1- et alpha 2-adrénergique et ont un potentiel de sélectivité uro-génitale. Ils sont donc utiles dans le traitement de l'adénome prostatique.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

3(2h)-pyridazinone derivatives and pharmaceutical... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3(2h)-pyridazinone derivatives and pharmaceutical..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3(2h)-pyridazinone derivatives and pharmaceutical... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1361012

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.