C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/501 (2006.01) C07D 319/20 (2006.01)
Patent
CA 2222724
The invention relates to R-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]- 3(2H)-pyridazinone of formula (1), and to S-2-[3-([1,4)benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazinone of formula (2), and to acid-addition salts thereof as well as pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for the preparation of the above compounds. The new starting compounds of formulae (4) and (5) are also involved in the scope of the invention. The compounds according to the invention possess .alpha.1- and .alpha.2-adrenoceptor antagonistic effects and urogenital selectivity. Thus, they are useful for the treatment of the benign prostate hyperplasia.
L'invention se rapporte aux composés R-2-[3-([1,4]benzodioxan-2-ylméthylamino)-1-propyl]-3(2H)-pyridazinone de formule (1), et S-2-[3-([1,4]benzodioxan-2-ylméthylamino)-1-propyl]-3(2H)-pyridazinone de formule (2), ainsi qu'aux sels d'addition d'acide desdits composés et aux compositions pharmaceutiques à base de ces composés. On décrit aussi un procédé relatif à l'élaboration de ces composés. Par ailleurs, le champ de l'invention s'étend aux nouveaux composés de départ correspondant aux formules (4) et (5). Les composés considérés sont des antagonistes du récepteur alpha 1- et alpha 2-adrénergique et ont un potentiel de sélectivité uro-génitale. Ils sont donc utiles dans le traitement de l'adénome prostatique.
Bidlo Margit
Druga Alice
Harsing Laszlo
Horvath Edit
Horvath Katalin
Fetherstonhaugh & Co.
Gyogyszerkutato Intezet Kft.
Ivax Drug Research Institute Limited Liability Company
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