C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/22 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) C07D 237/14 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2085796
The invention relates to racemic or optically active new 3(2H)-pyridazinone derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said 3(2H)-pyridazinone derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The new 3(2H)-pyridazinone derivatives according to the invention correspond to the general formula (I), (see formula I) wherein R1 represents hydrogen; phenyl; methyl optionally carrying a benzyloxy substituent; C1-4 alkyl optionally carrying a substituent of the formula R8R9N-, wherein R8 and R9 are independently C1-4 alkyl, or R8 and R9 form, together with the adjacent nitrogen atom, a 6-membered heterocyclic group optionally containing an oxygen atom or a group of the formula R10N-, wherein R10 stands for C1-4 alkyl optionally carrying a phenoxy substituent, or C3-5 alkenyl carrying a phenyl substituent, furthermore said C1-4 alkyl is optionally substituted by a phenyl carrying a methoxy or a methanesulfonylamino -2- substituent; or C3-5 alkenyl optionally carrying a phenyl or halophenyl substituent; A and B stand for hydrogen, halogen or a group of the general formula (II), (see formula II) wherein R2 and R3 are independently hydrogen or C1-4 alkyl, or together with the adjacent -N-(CH2)n N- group form a piperazine or homopiperazine ring; R4 represents hydrogen, C1-4 alkyl or phenyl, R5, R6 and R7 each stand for hydrogen, C1-4 alkoxy or amino optionally carrying a methanesulfonyl substituent; X is a single valency bond, an oxygen atom or a group of the formula -CH=CH-; m is 0 or 1, and n is 2 or 3, with the proviso that A and B are always different, and if one of A and B is hydrogen or halogen, the other stands for a group of the general formula (II), and acid addition salts thereof, and possess valuable antiarrhythmic effect.
Bodi Ilona
Czako Klara
Fekete Marton
Jaszlits Laszlo
Jednakovics Andrea
Egis Gyogyszergyar Nyrt.
Fetherstonhaugh & Co.
LandOfFree
3(2h)-pyridazinone derivatives and process for the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 3(2h)-pyridazinone derivatives and process for the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3(2h)-pyridazinone derivatives and process for the... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1953187