3 (2h) pyridazinones, processes for their preparation and...

Details 3 (2h) pyridazinones, processes for their preparation and... 3 (2h) pyridazinones, processes for their preparation and...

C - Chemistry, Metallurgy

07

D

167/224, 260/264

C07D 237/22 (2006.01) A61K 31/50 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2004538

ABSTRACT A 3(2H)pyridazinone of the formula: Image (I) wherein R1 is hydrogen, 2-propenyl, or straight chained or branched C1-C4 alkyl; each of R2 and R3 which may be the same or different, is hydrogen, or straight chained or branched C1-C3 alkyl; X is chlorine, or bromine; Y is hydrogen, halogen, nitro, amino, or -AR4 wherein A is oxygen, or sulfur, and R4 is hydrogen, straight chained, branched or cyclic C1-C8 alkyl, or Image wherein R5 is hydrogen, or straight chained or branched C1-C4 alkyl; and Ar is Image , Image or Image wherein each of Z1 and Z2 which may be the same or different, is hydrogen, halogen, straight or branched C1-C4 alkyl, or -OR6 wherein -R6 is straight or branched C1-C4 alkyl, and B is oxygen, sulfur, or -N=C- (to form a quinoline or pyridine ring); or a pharmaceutically acceptable salt thereof.

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