3',3'-n-bis-substituted macrolide lhrh antagonists

Details 3',3'-n-bis-substituted macrolide lhrh antagonists 3',3'-n-bis-substituted macrolide lhrh antagonists

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2325519

Disclosed are 3',3'-N-bisdesmethyl-3',3'-N-bis-substituted-6-O-methyl-11-deoxy- 11,12-cyclic carbamate erythromycin A derivatives of formula (I) which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, methods of using the compounds and the process of making the same.

Cette invention se rapporte à des dérivés d'érythromycine A de carbonate 3'-3'-N-bisdesméthyl-3'-3'-N-bis-substitué-6-O-méthyl-11-désoxy-11,12-cyclique de la formule (I), qui sont des antagonistes de l'hormone de libération de la lutéinostimuline (LHRH). Cette invention présente également des compositions pharmaceutiques contenant ces composés, des procédés d'utilisation de ces composés et le procédé de fabrication de ces composés.

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