3'-(4-morpholinyl)-and3'-(2-methoxy-4-morpholynil)-...

Details 3'-(4-morpholinyl)-and3'-(2-methoxy-4-morpholynil)-... 3'-(4-morpholinyl)-and3'-(2-methoxy-4-morpholynil)-...

C - Chemistry, Metallurgy

07

H

167/184, 260/208

C07H 15/252 (2006.01) C07H 19/02 (2006.01)

Patent

CA 2028841

- 22 - ABSTRACT NEW 3'-(4-MORPHOLINYL)- AND 3'-(2-METHOXY-4-MORPHOLINYL)- ANTHRACYCLINE DERIVATIVES Anthracycline glycosides of general formula I: Image wherein Z is hydrogen or methoxy; X represents hydrogen or hydroxy; R1 represents hydrogen, fluorine, hydroxy, methoxy or amino; R2 and R3 both represent hydroxy or one of R2 and R3 is hydrogen, nitro or amino and the other is hydroxy; and R4 and R5 represent hydrogen or one of R4 and R5 is hydrogen and the other is: hydroxy; and pharmaceutically acceptable salts thereof; with the provisos that: (i) where R2 and R3 are both hydroxy and Z is hydrogen then R1 represents hydroxy, fluorine or amino, and (ii) when both Z and R1 are methoxy and R2 and R3 are both hydroxy then R5 is hydroxy or both R4 and R5 are hydrogen.

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