3',6-substituted indirubins and their biological applications

Details 3',6-substituted indirubins and their biological applications 3',6-substituted indirubins and their biological applications

C - Chemistry, Metallurgy

07

D

C07D 209/40 (2006.01) A61K 31/404 (2006.01) A61K 31/496 (2006.01)

Patent

CA 2732232

Indirubin derivatives of formula (I) wherein R represents -(A)n-R1 or -CO- N(R2,R3) with .cndot. A being C1-C5 alkylene group, optionally substituted by one or several A1 radical, A1 being an halogen Br, OH, OR' or NH2, R4 being C1-C5 alkyl; - R1 being halogen, OH, N(R2, R3); R2 and R3, identical or different, being C1- C5 alkyl, optionally substituted by A1 such as above defined, or R2 and R3 are part of a cycle with 5 or 6 elements optionally comprising another heteroatom such as O or N; .cndot. n = 1-5. It also relates to the biological application thereof.

L'invention porte sur des dérivés d'indirubine de formule (I), dans laquelle R représente - (A)n-R1 ou -CO-N(R2,R3) avec A étant un groupe alkylène en C1-C5, éventuellement substitué par un ou plusieurs radicaux A1, A1 représentant un halogène Br, OH, OR4 ou NH2, R4 étant alkyle en C1-C5 ; - R1 représentant halogène, OH, N(R2, R3) ; R2 et R3, identiques ou différents, représentant alkyle en C1-C5, éventuellement substitué par A1 tel que défini ci-dessus, ou R2 et R3 font partie d'un cycle avec 5 ou 6 éléments comprenant éventuellement un autre hétéroatome tel que O ou N ; n = 1-5. L'invention porte également sur l'application biologique de ces dérivés.

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